https://www.readfrontier.org/stories/oklahoma-trying-to-return-its-2m-stockpile-of-hydroxychloroquine/
chazzed said:
To quote a recent post by janky1, "LOL":
https://www.readfrontier.org/stories/oklahoma-trying-to-return-its-2m-stockpile-of-hydroxychloroquine/
JUST IN: New study finds that the use of weight-adjusted hydroxychloroquine & azithromycin improved survival of ventilated COVID-19 patients by nearly 200% - medRxiv
— Breaking911 (@Breaking911) June 8, 2021
Please link the preprint study so we can review. I know you enjoy your premature victory lap but it's fair to actually show your work. There have been numerous conflicting studies on HCQ/AZM impact on COVID, so we can't rely on a random tweet from a RWNJ twitter account.hanky1 said:
Here we goJUST IN: New study finds that the use of weight-adjusted hydroxychloroquine & azithromycin improved survival of ventilated COVID-19 patients by nearly 200% - medRxiv
— Breaking911 (@Breaking911) June 8, 2021
Unit2Sucks said:Please link the preprint study so we can review. I know you enjoy your premature victory lap but it's fair to actually show your work. There have been numerous conflicting studies on HCQ/AZM impact on COVID, so we can't rely on a random tweet from a RWNJ twitter account.hanky1 said:
Here we goJUST IN: New study finds that the use of weight-adjusted hydroxychloroquine & azithromycin improved survival of ventilated COVID-19 patients by nearly 200% - medRxiv
— Breaking911 (@Breaking911) June 8, 2021
How many Breaking911 citations did hanky1 include in his PhD dissertation?hanky1 said:
Here we goJUST IN: New study finds that the use of weight-adjusted hydroxychloroquine & azithromycin improved survival of ventilated COVID-19 patients by nearly 200% - medRxiv
— Breaking911 (@Breaking911) June 8, 2021
Trump was right again, and the democrats and their PR machine media are responsible for the dead.BearForce2 said:Unit2Sucks said:Please link the preprint study so we can review. I know you enjoy your premature victory lap but it's fair to actually show your work. There have been numerous conflicting studies on HCQ/AZM impact on COVID, so we can't rely on a random tweet from a RWNJ twitter account.hanky1 said:
Here we goJUST IN: New study finds that the use of weight-adjusted hydroxychloroquine & azithromycin improved survival of ventilated COVID-19 patients by nearly 200% - medRxiv
— Breaking911 (@Breaking911) June 8, 2021
You can find your own links, this hasn't been a good month or year for "science", media, or truth.
bearister said:
I hope the unvaxed fat f@ucks in the South gobble it like mints when they get the variant from India.
MinotStateBeav said:bearister said:
I hope the unvaxed fat f@ucks in the South gobble it like mints when they get the variant from India.
You do realize some people actually HAD covid, they don't need the vaccine, they have the antibodies. I almost took the vax, but I am 100% certain I had it in March of 2020, It totally screwed up my taste buds, still to this day.
MinotStateBeav said:Trump was right again, and the democrats and their PR machine media are responsible for the dead.BearForce2 said:Unit2Sucks said:Please link the preprint study so we can review. I know you enjoy your premature victory lap but it's fair to actually show your work. There have been numerous conflicting studies on HCQ/AZM impact on COVID, so we can't rely on a random tweet from a RWNJ twitter account.hanky1 said:
Here we goJUST IN: New study finds that the use of weight-adjusted hydroxychloroquine & azithromycin improved survival of ventilated COVID-19 patients by nearly 200% - medRxiv
— Breaking911 (@Breaking911) June 8, 2021
You can find your own links, this hasn't been a good month or year for "science", media, or truth.
B.A. Bearacus said:How many Breaking911 citations did hanky1 include in his PhD dissertation?hanky1 said:
Here we goJUST IN: New study finds that the use of weight-adjusted hydroxychloroquine & azithromycin improved survival of ventilated COVID-19 patients by nearly 200% - medRxiv
— Breaking911 (@Breaking911) June 8, 2021
Comment by one of the authors:Quote:
Abstract
Introduction This observational study looked at 255 COVID19 patients who required invasive mechanical ventilation (IMV) during the first two months of the US pandemic. Through comprehensive, longitudinal evaluation and new consideration of all the data, we were able to better describe and understand factors affecting outcome after intubation.
Methods All vital signs, laboratory values, and medication administrations (time, date, dose, and route) were collected and organized. Further, each patient's prior medical records, including PBM data and available ECG, were reviewed by a physician. These data were incorporated into time-series database for statistical analysis.
Results By discharge or Day 90, 78.2% of the cohort expired. The most common pre-existing conditions were hypertension, (63.5%), diabetes (59.2%) and obesity (50.4%). Age correlated with death. Comorbidities and clinical status on presentation were not predictive of outcome. Admission markers of inflammation were universally elevated (>96%). The cohort's weight range was nearly 7-fold. Causal modeling establishes that weight-adjusted HCQ and AZM therapy improves survival by over 100%. QTc prolongation did not correlate with cumulative HCQ dose or HCQ serum levels.
Discussion This detailed approach gives us better understanding of risk factors, prognostic indicators, and outcomes of Covid patients needing IMV. Few variables were related to outcome. By considering more factors and using new methods, we found that when increased doses of co-administered HCQ and AZM were associated with >100% increase in survival. Comparison of absolute with weight-adjusted cumulative doses proves administration 80 mg/kg of HCQ with > 1 gm AZM increases survival in IMV-requiring Covid patients by over 100%. According to our data, HCQ is not associated with prolongation. Studies, which reported QTc prolongation secondary to HCQ, need to be re-evaluated more stringently and with controls.
The weight ranges of Covid patient cohorts are substantially greater than those of most antibiotic RCTs. Future clinical trials need to consider the weight variance of hospitalized Covid patients and need to study therapeutics more thoughtfully.
Quote:
First, the cumulative was not, for most pts, a measure of length of stay or determined by death. The most commonly used cumulative dose of HCQ = 2,400 mg. This dose/regimen was recommended, as noted in the paper by Yao et al., based upon computer modeling. The 2,400 mg dose was given over 5 days, 800 mg on Day and 400 mg on Days 2-5. The treating or consulting ID physician chose the cumulative dose.
In late March, the French data came out and some switched to the French regimen, 600 mg of HCQ x 10 days plus azithromycin x 5 days. Most pts received the 800 mg first day dose, which was started by the ER docs and was a click in the computer ordering system. The ID docs saw the pt the next morning. Many continued the pt on 400 mg per day for 4 more days. Others switched to 600 mg per day. So, by Day 5 on the latter regimen, the cumulative HCQ dose = 3,200 mg or > 3 gm or the cut-off used in our paper. In other words, it took just as long to get to > 3 gm and as it took to get to 2,400 mg.
In a simplistic way to control for length of stay (LOS), we analyzed the effect of >3gHCQ/ >1gAZM on outcome after removing those patients, who had a LOS <= 5 days. All 49 patients with a LOS <= 5 days expired; none took > 3,000 mg HCQ and > 1,000 mg AZM.
The 169 remaining patients serve as the "untreated" group and had a survival rate = 21.3%. The >3gHCQ />1gAZM group's survival rate = 48.6%. This difference = 27.3%, which is still large and highly statistically significant (difference = 27.3%; 95% C.I. = 10.1-43.7%; p = 0.0006).
In other words, even after eliminating all patients who had a LOS <= 5 days from the "untreated" group, the survival rate of the HCQ/AZM was more than 2.2-fold that of the "untreated" group. BTW, this type of analysis is heavily biased against showing a difference between treatment with HCQ, because the treatment may have an effect before Day 5.
Remember, most of the "untreated" group did receive HCQ, just <= 3 gm.
In other words, cumulative dose of HCQ was not a marker of survival. The cumulative HCQ dose was determined by the ID doctor seeing the pt. Different ID doctors interpreted the available data on HCQ differently. Essentially, they chose between the 2,400 mg without AZM or the 6,000 mg total HCQ dose with AZM or no HCQ at all. A few ID doctors split the middle and used ~3 gm of HCQ with AZM.
Many ID doctors did not use AZM with HCQ for fear or concern about prolonging the QTc interval on the ECG. We, instead, followed the QTc interval closely.
Weight-based HCQ cumulative dose was more strongly associated with survival and absolute cumulative dose. This fact essentially rules out HCQ cumulative dose being a marker of survival as well.
Lighter pts reached a weight-based cumulative HCQ dose well before heavier pts. If a pt weighed 50% of another pt, it took 50% of the days to reach a given weight-based HCQ cumulative dose.
These pts typically received 800 mg HCQ on Day 1 and then 600 mg per day.
A 60 kg pt reached 40 mg/kg by Day 4, while a 120 kg pt, didn't reach 40 mg/kg until Day 8.
SMS
And no one here is doubting your intelligence.AunBear89 said:
I think his point is that you are not as smart as you think you are.
BearForce2 said:And no one here is doubting your intelligence.AunBear89 said:
I think his point is that you are not as smart as you think you are.
Big C said:
Now that we know Hydroxychloroquine is indeed actually a wonder drug and now that we know that the area outside the White House wasn't cleared so that Trump could walk out and hold up the Bible and now that we know that the patriotic Capitol protests on 1/6 do not merit further investigation, I have one question:
When's that Reinstatement, baby? It will have the largest crowd EVER to attend a Presidential Reinstatement!!!
Big C said:
Can we work in fruits somewhere? When visiting in-laws and family in Florida and West Virginia, respectively, I always told them I'm from the land of fruits and nuts before they got a chance to say it. Preemptive strike. Then we proceeded to get along fine.
dajo9 said:Big C said:
Can we work in fruits somewhere? When visiting in-laws and family in Florida and West Virginia, respectively, I always told them I'm from the land of fruits and nuts before they got a chance to say it. Preemptive strike. Then we proceeded to get along fine.
I didn't get along with my Missouri relatives. I don't preemptively surrender. I asked them why they were talking nonsense.
Big C said:dajo9 said:Big C said:
Can we work in fruits somewhere? When visiting in-laws and family in Florida and West Virginia, respectively, I always told them I'm from the land of fruits and nuts before they got a chance to say it. Preemptive strike. Then we proceeded to get along fine.
I didn't get along with my Missouri relatives. I don't preemptively surrender. I asked them why they were talking nonsense.
How did they explain their talking nonsense?
In these types of situations, I feel like non-engagement is totally different than surrender. Better to have a few laughs and not talk politics. If some of my (distant) right-wing family members really want to debate things with me, fine, we can do that, and I will eviscerate them. Problem is, they won't admit defeat, even to themselves. And then life goes on...
The New York Times, which previously called the COVID-19 lab leak hypothesis a "fringe ... conspiracy theory", has just won a Pulitzer Prize for its coverage of the pandemic
— Amber Athey (@amber_athey) June 11, 2021
Quote:
Pulitzer is the prize for most believable propaganda.
dajo9 said:
Bearforce2 is relentless in his attacks on the media because his political side is so stupid, corrupt, dishonest, and incompetent. Attacking the messenger is all they've got.
John Brennan and James Clapper spent their time within the US Security State purposely lying to the public, then when they left, they got hired by the two liberal cable outlets that pretend to be so upset by disinformation.
— Glenn Greenwald (@ggreenwald) June 12, 2021
What else do you need to know about them? pic.twitter.com/x0LSuQyTKJ
BearForce2 said:dajo9 said:
Bearforce2 is relentless in his attacks on the media because his political side is so stupid, corrupt, dishonest, and incompetent. Attacking the messenger is all they've got.John Brennan and James Clapper spent their time within the US Security State purposely lying to the public, then when they left, they got hired by the two liberal cable outlets that pretend to be so upset by disinformation.
— Glenn Greenwald (@ggreenwald) June 12, 2021
What else do you need to know about them? pic.twitter.com/x0LSuQyTKJ
You spent the last 4+ years believing lies that you wanted to believe. That's called delusion.
dajo9 said:BearForce2 said:dajo9 said:
Bearforce2 is relentless in his attacks on the media because his political side is so stupid, corrupt, dishonest, and incompetent. Attacking the messenger is all they've got.John Brennan and James Clapper spent their time within the US Security State purposely lying to the public, then when they left, they got hired by the two liberal cable outlets that pretend to be so upset by disinformation.
— Glenn Greenwald (@ggreenwald) June 12, 2021
What else do you need to know about them? pic.twitter.com/x0LSuQyTKJ
You spent the last 4+ years believing lies that you wanted to believe. That's called delusion.
That was like every week during the Trump Administration
Quote:
A new study shows that the controversial drug hydroxychloroquine touted by former President Donald Trump increased the survival rate of severely ill coronavirus patients.
NIH now recommends Vitamin C, D3 and Zinc for prevention and treatment of Covid-19. The rest of us who have recommended it for the past 18 months don't even want an apology.
— Brian Lenzkes, MD (@BrianLenzkes) September 16, 2021
hanky1 said:NIH now recommends Vitamin C, D3 and Zinc for prevention and treatment of Covid-19. The rest of us who have recommended it for the past 18 months don't even want an apology.
— Brian Lenzkes, MD (@BrianLenzkes) September 16, 2021
Give it a little more time.
hanky1 will have the last laugh
Hey all, the original article that I read this in today was retracted. I do not want to spread misinformation. I will double check the source. Consider it fake news regarding NIH until further notice. https://t.co/qTeEaH14JS
— Brian Lenzkes, MD (@BrianLenzkes) September 17, 2021
HCQ - banned
— Dr. Brian Tyson, MD πΊπΈ (@btysonmd) September 16, 2021
Ivermectin- banned
NAC - limited
D3 - limited for active IV form
Monoclonal Antibody- now limited
What does this tell you?
Oops.B.A. Bearacus said:hanky1 said:NIH now recommends Vitamin C, D3 and Zinc for prevention and treatment of Covid-19. The rest of us who have recommended it for the past 18 months don't even want an apology.
— Brian Lenzkes, MD (@BrianLenzkes) September 16, 2021
Give it a little more time.
hanky1 will have the last laugh
You undoubtedly will be laughed at last. Last is a fitting culmination of throughout and all along the way.Hey all, the original article that I read this in today was retracted. I do not want to spread misinformation. I will double check the source. Consider it fake news regarding NIH until further notice. https://t.co/qTeEaH14JS
— Brian Lenzkes, MD (@BrianLenzkes) September 17, 2021