Apologies for beating a dead horse but for those who are interested:
https://pharma.elsevier.com/pharma-rd/three-drug-development-strategies-to-combat-2019-novel-coronavirus/Quote:
3. Investigate compounds that target autophagy
Autophagy is a pathway used by cells to recycle damaged proteins and destroy pathogens, but some viruses can hijack the autophagy pathway to manufacture virus proteins [4]. Therefore, whether autophagy inhibition or activation would be more effective against SARS-CoV-2 infection needed further exploration.
We used Pathway Studio and found 406 compounds that inhibited and 802 compounds that activated autophagy. In total, 33 of the compounds that activated (and none of the compounds that inhibited) autophagy were listed among the 121 drugs reported effective against coronaviruses. In addition, Gassen et al. found that blocking autophagy attenuation inhibited MERS coronavirus replication [5]. Both these findings suggest that activation of autophagy inhibits SARS-CoV-2 replication and autophagy-activating compounds should be investigated as antivirals.
I presume the compounds that they studied were all in vitro lab studies. But 33 of the 121 compounds that were effective against coronavirus ACTIVATED autophagy. The western/pharma model to find a drug to "cure" people is going to be 5 years too late for this pandemic.
What else promotes autophagy that doesn't require FDA fast track approval? Fasting. I'm hearing from the ICU's that BY FAR the most common characteristic of those getting vented is obesity. IIt is safe to say that the obese patients have not experienced much or if any substantive autophagy while they were breathing on their own. Food addiction and continuous processed carb consumption is coming home to roost. The thing is autophagy is not weight dependent. Everyone can physiologically promote it, you just have to fast.
BTW, the other thing that upregulates autophagy is exercise. But most people eat before or after exercise which stops autophagy. So unless you are working out 5-10 hours a day, you can't get the autophagy that fasting gets you. Also, sufficient sleep also upregulates autophagy, because most people aren't eating while they are sleeping.