oskidunker said:
I am not a fan of Newsome and his lengthy press conferences which usually don't tell you much. However the shortage of the vaccine is mostly the problem. They schedule appointments based on predicted doses they will receive. Probably should wait to see what they have before scheduling.
My fear is by the time most people are vaccinated, the virus will have mutated enough so theshots we get now may not be very effective. Those getting vaccinated later in the year with a modified vaccine COULD be better off. I hope that is not the case ir we may never get over this thing.
Perhaps someone could explain how and why a virus mutates. Sounds like a living being.
To over simplify things a bit:
Virus's take over the dna replication portion of the cells in your body. They basically hijack the existing system to replicate itself instead of the cells themselves.
The replication is literally copying the DNA strands...the strands are large enough that errors in copying aren't that uncommon.
Most errors in copying will be detrimental and cause the newly copied section of DNA to be unusable. Some will be beneficial to the virus. Just like evolution, the virus most likely to procreate (copy) and survive will be the one that survives. If those random mutations happen to make the virus invade more cells, replicate faster, or be more contagious, they will be more likely to succeed.
Gotta keep in mind, the raw number of virus particles in a person is quite large. This site claims:
"100,000,000-100,000,000,000 virions during peak infection"
https://www.medrxiv.org/content/10.1101/2020.11.16.20232009v1Each one of those virions is the result of a copy process which was prone to error.
All a vaccine does is teach your existing immune system how to fight the virus. If the virus changes enough due to these random mutations during the hundreds of millions of copies per infected individual, it may be enough of a change that your antibodies are unable to attack it anymore, making the vaccine ineffectual. That is the concern.
Obviously the faster we can get a vaccine out and distributed the fewer overall copies occur and the less mutation there is...but the vaccines have to be tested for efficacy and safety, during which time mutations can and will occur.